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Symbol Name ID |
Kras
Kirsten rat sarcoma viral oncogene homolog MGI:96680 |
| Darker colors indicate more annotations |
| Human Phenotypes | Gastrointestinal hemorrhage |
Bruising susceptibility |
Abnormality of the cardiovascular system |
Abnormal cardiovascular system morphology |
Atrial septal defect |
Patent foramen ovale |
Ventricular septal defect |
Cardiac diverticulum |
Abnormal heart valve morphology |
Mitral valve prolapse |
Tricuspid valve prolapse |
Abnormal pulmonary valve morphology |
Hypertrophic cardiomyopathy |
Coarctation of aorta |
Pulmonary artery stenosis |
Patent ductus arteriosus |
Peripheral arteriovenous fistula |
Cerebral arteriovenous malformation |
Abnormal cerebral vascular morphology |
Transient ischemic attack |
Pulmonic stenosis |
Abnormal EKG |
Arrhythmia |
Abnormality of the lymphatic system |
Lymphadenopathy |
Follicular hyperplasia |
Abnormality of the spleen |
Splenomegaly |
Hepatosplenomegaly |
Hemangioma |
Cavernous hemangioma |
Visceral angiomatosis |
| Disease(s) Associated with KRAS | ||||||||||||||||||||||||||||||||
| arteriovenous malformations of the brain | ||||||||||||||||||||||||||||||||
| autoimmune lymphoproliferative syndrome type 4 | ||||||||||||||||||||||||||||||||
| cardiofaciocutaneous syndrome | ||||||||||||||||||||||||||||||||
| cardiofaciocutaneous syndrome 2 | ||||||||||||||||||||||||||||||||
| linear nevus sebaceous syndrome | ||||||||||||||||||||||||||||||||
| Lynch syndrome | ||||||||||||||||||||||||||||||||
| multiple myeloma | ||||||||||||||||||||||||||||||||
| Noonan syndrome | ||||||||||||||||||||||||||||||||
| Noonan syndrome 3 | ||||||||||||||||||||||||||||||||
| oculoectodermal syndrome | ||||||||||||||||||||||||||||||||
| pancreatic cancer |
| Mouse Phenotypes | abnormal brain vasculature morphology |
abnormal placental labyrinth vasculature morphology |
absent vitelline blood vessels |
arteriovenous malformation |
spleen vascular congestion |
increased myocardial fiber number |
thin myocardium |
conotruncal ridge hyperplasia |
abnormal heart morphology |
double outlet right ventricle |
abnormal atrioventricular valve morphology |
ventricular septal defect |
enlarged heart |
heart hyperplasia |
small heart |
thick aortic valve |
thin ventricular wall |
pericardial edema |
abnormal cardiovascular system physiology |
increased cardiac output |
hemorrhage |
intracranial hemorrhage |
increased cardiac muscle contractility |
abnormal fetal cardiomyocyte proliferation |
abnormal myocardial fiber physiology |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||
| Krastm1Mok/Krastm1Mok | ||||||||||||||||||||||||||
| Krastm1Tyj/Krastm1Tyj | ||||||||||||||||||||||||||
| Krastm4.1Bbd/Krastm4.1Bbd | ||||||||||||||||||||||||||
| Krastm4.1Tyj/Kras+ | ||||||||||||||||||||||||||
| Krastm4Tyj/Kras+ Tg(Prm-cre)58Og/0 (conditional) |
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| Krastm4Tyj/Kras+ Meox2tm1(cre)Sor/Meox2+ (conditional) |
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| Krastm4Tyj/Kras+ Tg(Cdh5-cre/ERT2)1Rha/0 (conditional) |
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| Krastm4Tyj/Kras+ Tg(Slco1c1-icre/ERT2)1Mrks/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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